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NCBI Bookshelf. While many agents have been developed to aid in weight loss, few have withstood critical assessment of safety and efficacy. Weight loss agents are held to a high standard for safety and tolerability, because they are often used by otherwise healthy individuals driven more by concerns over appearance than health.
Furthermore, all weight loss medications should be used as a part of a coordinated weight loss program that includes modification of behaviors, a reduced calorie diet and increased physical activity or exercise. Drugs for weight loss can be separated into those that suppress appetite such as diethylpropion and phentermine and those that block absorption of calories orlistat.
The anorexic agents that have been used for weight loss include sympathomimetic agents such as diethylpropion, and phentermineserotonin and norepinephrine reuptake inhibitors bupropion, fluoxetine, sibutramineserotonin agonists lorcaserinGABAergic agents topiramate, zonisamide and cannabinoid antagonists rimonabant.
The cannabinoid antagonist rimonabant was shown to induce weight loss but was Green tea fat burner and phentermine approved in the United States because of concerns over suicidal ideation and behaviors associated with its use. Sibutramine Meridia which has both sympathomimetic activity as well as serotonin and norepinephrine reuptake inhibitory activity, was approved in the United States in and used widely for several years in the United States, but was then withdrawn in because of concerns over increased risks for cardiovascular adverse events including myocardial infarction and stroke.
Lorcaserin Belviqa serotonin agonist, was approved as a weight loss agent in but was withdrawn in because of concerns of increased risk for cancer. Second generation weight loss agents still in current use include the combination of phentermine and topiramate Qsymia: ; a fixed dose combination of the antidepressant bupropion and the opioid receptor antagonist naltrexone Contrave: ; and the injectable glucagon-like peptide-1 GLP-1 agonist liraglutide which is approved and used for type 2 diabetes Victoza: 20xx and, when given in a higher dose, for weight loss Saxenda Drugs that suppress appetite generally affect appetite centers in the central nervous system CNS and can have other CNS effects such as nervousness, excitability, insomnia, mood changes, and headache.
Drugs that affect absorption of nutrients often have other gastrointestinal side effects such as diarrhea, flatulence and abdominal bloating. Green tea fat burner and phentermine injury is rare with all of the currently approved medications for weight loss. In contrast, serious hepatotoxicity has been linked to several over the counter and herbal preparations promoted as Green tea fat burner and phentermine with weight loss usnic acid, ephedra, green tea, and Garcinia cambogia.
Turn recording back on. National Center for Biotechnology InformationU. Drug Records. Search term. The following weight loss agents are discussed individually: Bupropion. Anti-obesity drugs: a review about their effects and safety. Diabetes Metab J. Long-term drug treatment for obesity: a systematic and clinical review. Diet, drugs, devices, and surgery for weight management.
Med Lett Drugs Ther. Obesity pharmacotherapy. Med Clin North Am. Copyright Notice. Weight Loss Agents. Support Links. Related information. Similar articles in PubMed.

Review Long-term effects of weight-reducing drugs in people with hypertension. Cochrane Database Syst Rev. Epub Mar 2. Other Antidepressants. Handb Exp Pharmacol. G Ital Cardiol Rome. Review Current and emerging pharmacotherapies for obesity in Australia.
Obes Res Clin Pract. Epub Aug Comparison table: some FDA-approved drugs for weight management. Epub Jun 4. Recent Activity. Clear Turn Off Turn On. Support Center Support Center. External link. Please review our privacy policy.
People who have long been struggling with their weight are all probably asking the same questions: What is the best weight loss program?
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